Pre- and post-sexual exposure prophylaxis of HIV: An update
- PMID: 28442797
- PMCID: PMC5389206
- DOI: 10.4103/ijstd.IJSTD_26_17
Pre- and post-sexual exposure prophylaxis of HIV: An update
Abstract
Pitfalls in current HIV prevention strategies include late HIV testing, vulnerability among youth and females; lack of emphasis on treatment, low acceptance of circumcision, and nonavailability of protective vaccines. Continuing high-risk sexual behavior, forceful sex, coercive and nonconsensual sex, rape, and unprotected sexual activities make women the most vulnerable to acquisition of sexually transmitted infection/HIV and necessitates a more radical approach of prevention in high-risk individuals who do not have HIV. Preexposure prophylaxis is defined as the administration of antiretroviral drugs to an uninfected person before potential HIV exposure to reduce the risk of infection and continued during risk. The rationale of this approach is to administer preventive dose of drug(s) before exposure to HIV so the moment virus enters the body, HIV replication is inhibited and HIV is not able to establish permanent infection. Postexposure prophylaxis (PEP) following potential sexual exposure is an important form of nonoccupational PEP which is an emergency intervention to abort HIV acquisition arising from exposure to HIV-infected blood or potentially infectious bodily fluids following sexual exposure.
Keywords: Emtricitabine; HIV; postexposure prophylaxis following potential sexual exposure; preexposure prophylaxis; tenofovir.
Conflict of interest statement
There are no conflicts of interest.
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References
-
- Benn P, Fisher M, Kulasegaram R. BASHH; PEPSE Guidelines Writing Group Clinical Effectiveness Group. UK guideline for the use of post-exposure prophylaxis for HIV following sexual exposure (2011) Int J STD AIDS. 2011;22:695–708. - PubMed
-
- Training modules for medical officers on HIV Care and treatment (Including ART) NACO: Ministry of Health and Family Welfare; 2007. pp. 159–75.
-
- US Public Health Service. Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2014 Clinical Practice Guideline. [Last cited on 2014 Oct 05]. Available from: http://www.cdc.gov/hiv/pdf/PrEPguidelines2014.pdf .
-
- The Hindu: Pre- Exposure Prophylaxis in Gay Men. 2015. Sep 13, [Last accessed on 2017 Jan 10]. Available from: http://www.thehindu.com/sci-tech/health/preexposure-prophylaxis-prevents... .