A lot has happened since the events of End of the Spider-Verse. Doctor Octopus has gotten a taste of what it means to be Superior Spider-Man. Peter Parker experienced a reality where his Uncle Ben survived -- only to be brought back to face his old universe -- and adjust to working with a sidekick he can't remember. Meanwhile, Bailey Briggs has to re-adjust to the world and a mentor who doesn't remember him -- while re-educating the hero about the enemies he's completely forgotten. Now, another enemy, Supernova, a victim of Superior Spider-Man, has surfaced and is out for revenge. The problem is that she's hunting the wrong Spider-Man.